The tumor occurs in immunosuppressed individuals such as HIV infected people and kidney transplant patients. A new human herpesvirus, HHV-8, has been found associated with Kaposi's Sarcoma. We are culturing HHV-8 and have achieved its limited growth. We have helped to develop a serologic test to detect antibodies to HHV-8 in KS patients and the normal population. Up to 25% of healthy adults have antibodies to the virus and unless these people are immune suppressed, KS will not develop. Our objective is to isolate HHV-8 consistently in culture and develop procedures for evaluation of drugs against the virus and eventually to develop a vaccine against this virus.